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When it is desired to replace a monoamine oxidase inhibitor with amitriptyline, a minimum of 14 days should be allowed to elapse after the former is discontinued? La absorción percutánea de la tretinoína, determinada por la excreción acumulada del medicamento radiomarcado en orina y heces fecales, fue calculado en hombres y mujeres sanos después de la aplicación diaria simple o repetida de 005%, 01% ó 05% de la formulación en crema de la tretinoína ó 001% de la formulación en gel de la tretinoína, a dosis de 100, 150 ó 500 mg.